Furthermore, we showed that steppogenin suppressed inducible NF-kB activation and the subsequent induction of proinflammatory mediators, such as NO, PGE2, IL-1β, IL-6, TNF-α, IL-12 and that it blocked the neuronal disorders including Alzheimer’s disease, Parkinson’s disease, and stroke [33,34,35]. Here, NFKB1 is linked to early-onset autosomal dominant Alzheimer disease.