TGFB1 and neoplasm: Activated platelets, being an important source of transforming growth factor β (TGF-β), can induce epithelial-to-mesenchymal transition (EMT), which may occur either due to platelet extravasation and their interaction with the tumor cells in situ [11] or due to the occurrence of complexes with migrating cells formed in the blood vessel that maintain the invasive potential of tumor cells [12,13].