CD8A and skin infection: Prior to this work, only one study had addressed the question of immunodominance loss in HSV-1, wherein B6 mouse skin infection with the HSV-1 L8A point mutation in the gB498-505 epitope was shown to induce a normal-sized expansion of HSV-specific CD8+ T cells in the spleen that lacked any specificity for the immunodominant gB498-505 epitope [33].