GOT2 and type 1 diabetes mellitus: Additionally, it is important to differentiate amongst three putative mechanisms to explain the increased LC-CoA and lipid accumulation in T1D cells: (1) cellular trapping of FA in cytosolic LC-CoA due to increased expression, activity or localization of acyl-CoA synthetases (ACS), (2) increased cytosolic acyl CoA or fatty acid binding proteins (FABP) or (3) preferential triglyceride synthesis relative to FA oxidation.