Therefore, the EMT may be considered as molecular mechanism of acquisition of invasive properties as well as enhancing tumor aggressiveness and migratory potential through involvement of regulatory pathways (mainly transforming growth factor β (TGF-β), phospahtydylinositol-3-kinase (PI3K) and mitogen-associated protein kinase (MAPK)) and particular genes (E-cadherin, β-catenin, fibronectin, vimentin and matrix metalloproteases) [8]. Here, CDH1 is linked to neoplasm.