Firstly, we examined the significance of three hormone receptors: AR, ESR1, ESR2 in the biology of prostate cancer regarding the effect of their expression on tumor recurrence according to patient’s age (four age groups: ≤50, 51–60, 61–70, 70> years old) through disease-free survival (DFS) analysis. Here, ESR2 is linked to Familial prostate cancer.