In cancers from patients older than 70 years more significant seems to be the upregulation of key transcription factor SNAI1 and decreased expression of genes responsible for epithelial phenotype KRT19, CDH1, OCLN and MUC1. Summarizing, our analysis shows distinct and biologically significant differences in expression profile of sex hormone receptors as well as epithelial to mesenchymal transition genes that are associated with disease progression depicted as Gleason score. The gene discussed is OCLN; the disease is cancer.