ESR1 and neoplasm: Admittedly, the group sizes were much smaller (≤50: 5, 51–60: 18, 61–70: 25, 70>: 4 normal samples vs ≤50: 35, 51–60: 188, 61–70: 237, 70>: 37 tumor samples), but we found significant changes in expression of hormone receptors: lower expression of AR in groups ≤50 and 70> years old and its higher expression in groups 51–70, although no visible changes in both estrogen receptors, possibly indicating that tumors in older patients result from hyperplasia of the prostate and seem to be more normal-like (Fig 1E).