In contrast, ESR1 did not show any importance in groups of ≤50 and 70> years old in tumor recurrence, although its lowered expression was associated with better prognosis in remaining groups of 51–60 and 61–70 years old (HR = 7.95, p<0.001; HR = 2.75, p = 0.0053). The gene discussed is ESR1; the disease is neoplasm.