SMAD3 and prostate neoplasm: In particular, we found primarily overexpression of CTNNB1, CDH1, SMAD2, SMAD3, TCF3, LEF1 in younger patients and overexpression of SNAI1 and underexpression of KRT5, KRT19, OCLN, CDH2 and MUC1 which clearly indicates different characteristics of prostate tumor in younger vs older patients (Fig 6).