However, it was demonstrated that PCa with germline Breast Related Cancer Antigen (BRCA)1/2 mutations were more frequently associated with Gleason ≥ 8 (p = 0.00003), T3/T4 stage (p = 0.003), nodal involvement (p = 0.00005), and metastases at diagnosis (p = 0.005) than in non-carriers PCa, resulting in reduced cancer-specific survival [17]. Here, BRCA1 is linked to posterior cortical atrophy.