Recently, a whole exome and transcriptome analysis, performed on 150 biopsies from primary or metastatic PCa (mPCa) tissue, showed that germline or somatic aberration in DNA repair genes, such as AR, ETS genes, TP53, PTEN, PIK3CA/B, R-spondin, BRAF/RAF1, APC, β-catenin, ZBTB16/PLZF, BRCA2, BRCA1, and ATM, are representative in both primary and advanced PCa [14,15]. Here, PIK3CA is linked to posterior cortical atrophy.