For example, 12-week supplementation with 100 mg resveratrol significantly ameliorated arterial stiffness and decreased serum diacron-reactive oxygen metabolites (d-ROMS)-a measure of oxidative stress- in type 2 diabetics [107], supplementation with 500 mg/day resveratrol significantly decreased oxidative stress (measured as serum MDA) in subjects with ulcerative colitis [108], and supplementation with α-lipoic acid in type-2 diabetics significantly increased SOD and GPx, and decreased MDA in subjects compared to baseline measures and compared to the placebo-control group [109]. The gene discussed is SOD1; the disease is type 2 diabetes mellitus.