PIK3C2A and myocardial infarction: Arsenic significantly elevated Creatine Kinase (CK) [62] and Creatine Phosphokinase (CPK) [68], which indicate stress to the heart, and elevated Creatine Kinase from muscle and brain (CK-MB) [70], as well as levels of serum troponin [54], which are cardiac markers used to diagnose acute myocardial infarction.