At the same time, we observed a substantial (82-fold) decrease in the expression of FANCA in GIST T-1R cells when compared to the GIST T-1 cell line, thus indicating the potential sensitivity of IM-resistant GIST T-1R cells to DNA cross-linking agents due to the defective FANC-associated DNA repair pathway. The gene discussed is FANCA; the disease is gastrointestinal stromal tumor.