TPM1 and tongue squamous cell carcinoma: In tongue squamous cell carcinoma (TSCC), which is the most frequent type of OSCC, overexpression of miR-21 was correlated with low expression of two of its target genes, Tpm1 and Pten. It was demonstrated that miR-21 overexpression promotes anchorage-independent growth of OSCC cells, partially by targeting Tpm1 [45].