Tang et al. found an overexpression of Hotair in samples from OSCC patients, especially with lymph node metastases [109], these results being in accordance with the aforementioned studies on Hotair. In oral cancer, Hotair sustains cell proliferation [119], invasion and metastatic processes by targeting Ezh2 and repressing E-cadherin [120]. The gene discussed is HOTAIR; the disease is lip and oral cavity carcinoma.