MACROH2A1 and hepatocellular carcinoma: MacroH2A1 seems to be mechanistically dispensable for RS and DIS, as the number of β-galactosidase positive cells in the liver of aged macroH2A1 knock-out (KO) mice is identical to those of aged matched wild type littermates, as well as in H2O2-treated hepatoma cells KO for macroH2A1 compared to control cells [14].