Moreover, guardians of genome stability involved in cancer such as SWItch/Sucrose non-fermentable (SWI/SNF) helicase, α-thalassemia/MR, X-linked (ATRX) and aprataxin-PNK-like factor (APLF) act as negative and positive regulators, respectively, of macroH2A1’s chromatin association [63,64]. This evidence concerns the gene MACROH2A1 and cancer.