Since, as described above, depletion of the whole macroH2A1 gene [46] has also, although milder, anti-adipogenic effects in mice fed a HF diet, we argue that macroH2A1.1 has a stronger pro-adipogenic role than the protective one of macroH2A1.2, supported also by the macroH2A1.1-dependent regulation of EZH2/Wnt signaling in differentiating pre-adipocytes [49]. The gene discussed is MACROH2A1; the disease is hydrops fetalis.