We and others reported that macroH2A1 isoforms are found to be upregulated at the protein levels in the liver of mice displaying NAFLD as a simple lipid accumulation or displaying its inflammatory form non-alcoholic steatohepatitis (NASH), induced either by a high-fat diet or by a diet deficient in methionine and choline [28,42]. This evidence concerns the gene MACROH2A1 and metabolic dysfunction-associated steatohepatitis.