LPL might then be added to the list of proteins implicated in the activation of CLL proliferative pool together with integrins such as CD49d, metalloproteinases (MMP-9), antiapoptotic molecules (BCL2) as well as chemokines (CCL3, CCL4, CXCL12) [68,69]. This evidence concerns the gene CXCL12 and B-cell chronic lymphocytic leukemia.