The fact that CLL B-cells display heparan sulfate proteoglycans on their surface [62], invites to speculate about whether LPL localization on the cellular membrane could affect the biological behavior of CLL cells, by favoring cell spreading, migration and intracellular signaling following activation of the tumoral clone by an activated microenvironment. The gene discussed is LPL; the disease is B-cell chronic lymphocytic leukemia.