Somatic mutations in the human gene EIF1AX encoding eIF1A are frequently associated with uveal melanomas (UM) associated with disomy for chromosome 3, and all of the EIF1AX mutations sequenced thus far produce in-frame substitutions or deletions of one or more residues in the first 15 residues of the NTT (Martin et al., 2013). This evidence concerns the gene EIF1 and uveal melanoma.