HLA‐G G*0106 variant contributed by the father has been shown to increase the risk for preeclampsia in multigravida pregnancies irrespective of sex.37 Other factors, such as differences in endocrine and vascular physiology, likely have important roles in regulating fetal‐maternal interactions between male and female fetuses.4, 38 Taken together with our current results, these data suggest that maternal immune responses are variable based on the sex of the fetus, requiring researchers to consider fetal sex in experimental design. This evidence concerns the gene HLA-G and preeclampsia.