The Low-B patient was a 65-year-old HER2 0 group woman with a 16 × 15 mm lesion of the scirrhous subtype of invasive ductal carcinoma, no lymph node metastasis and immunohistochemistry staining showing 90% ER, 80% PgR, and 5% Ki-67. The gene discussed is ERBB2; the disease is invasive ductal breast carcinoma.