IGHE and Irritability: In contrast, several reports suggest that TLR7 ligands have potential as adjuvants for the treatment of Th2-mediated allergic diseases: in an experimental mouse allergy model, the TLR7 ligand Imiquimod significantly inhibited chronic inflammation, persistent airway hyperreactivity (AHR), and airway remodeling, while reducing serum IgE levels and Th2 cytokines in BAL fluids [24].