The antidiabetic properties of the flavonoids are primarily based on their effect on diverse molecular objectives and in the regulation of various pathways, like the reduction of apoptosis, improvement of proliferation of the pancreatic β-cells, promoting the secretion of insulin through regulation of glucose metabolism in hepatocytes on improving hyperglycemia, and decreasing insulin resistance, inflammation, and oxidative stress in adipocytes and skeletal myofibrils. This evidence concerns the gene INS and Hyperglycemia.