PPARGC1A and obesity due to melanocortin 4 receptor deficiency: In the context of the chronic metabolic condition of obesity, increases in mitochondrial FA oxidative capacity may be mediated in part by peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α), a protein that promotes the transcription of genes associated with FA metabolism and is upregulated by a high-fat diet and obesity in rodent models [6, 7].