According to Yu et al. [86] intraperitoneal injection Salvia miltiorrhiza 100 mg/kg/d for 4 weeks improved the heart function of diabetic rats and protected against cardiomyopathy by downregulating thrombospondin-1 (TSP-1) and TGF-β1 in myocardial tissue. This evidence concerns the gene THBS1 and cardiomyopathy.