Compared with the nontreated 3xTg-AD mice, the crossing number (p < 0.05; Figure 4(d)), the percentage of distance traveled (p < 0.05; Figure 4(g)), and the percentage of time spent (p < 0.05; Figure 4(h)) in the target quadrant were significantly increased, and the probe time was significantly decreased in 3xTg-AD mice after the treatment of Rg1. Here, PPP1R3A is linked to Alzheimer disease.