CPLX2 and Alzheimer disease: Among these proteins, a total of 27 proteins, including memory-related proteins such as synaptosomal-associated protein 25 (SNP25), synapsin-2 (SYN2), and complexin-2 (CPLX2), in 3xTg-AD mice compared with WT mice were significantly downregulated, while a total of 20 proteins were significantly upregulated.