In this study, we found that the expression of SNP25 was significantly decreased in the hippocampus of 3xTg-AD mice compared with the WT mice, while Rg1 treatment could significantly modulate the expression of this protein and alleviate memory impairment of 3xTg-AD mice, suggesting an involvement of SNP25 in memory impairment of 3xTg-AD mice as observed and the protective effects of Rg1 on memory. Here, PPP1R3A is linked to memory impairment.