A block in autophagy flux, increase in p62 levels and an accumulation of autophagosomes have been demonstrated in dopaminergic neurons generated from PD patient-derived induced pluripotent stem cells (iPSCs) expressing LRRK2-G2019S at endogenous levels (Sánchez-Danés et al., 2012). The gene discussed is LRRK2; the disease is Parkinson disease.