Attention has also been given to the interactions between Mn and PD-linked gene products including α-synuclein, Parkin, PINK1, DJ-1, LRRK2, ATP13A2, and VPS35, as recently discussed in these reviews (Covy and Giasson, 2011; Roth, 2014, Peres et al., 2016). This evidence concerns the gene PRKN and Parkinson disease.