LRRK2 and Parkinson disease: Although more than 100 LRRK2 mutations have been reported, only a few such as (N1437H, R1441C, R1441G, R1441H, Y1699C, G2019S, and I2020T0) have been proven to cause PD and two have been nominated as risk factors (R1628P and G2385R) (Dächsel and Farrer, 2010; Paisan-Ruiz et al., 2013).