PINK1 deficient and PD-associated mutant models display reduced mitochondrial membrane potential, ATP levels, reduced respiratory capacity via complex I and IV activity, increased mitochondrial calcium levels, sensitized mitochondrial permeability transition pore opening and increased ROS production (Gautier et al., 2008, 2012; Piccoli et al., 2008; Dagda et al., 2009; Gandhi et al., 2009; Gegg et al., 2009; Liu W. et al., 2009; Morais et al., 2009, 2014; Cui et al., 2010; Heeman et al., 2011). This evidence concerns the gene PINK1 and Parkinson disease.