Although little is known about the physiological roles of Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2) or its role in PD pathology, several mutations in the CHCHD2 gene cause an autosomal dominant form of late-onset PD and dementia with Lewy bodies (Funayama et al., 2015; Ogaki et al., 2015; Koschmidder et al., 2016). This evidence concerns the gene CHCHD2 and Parkinson disease.