Lack of S100A8/A9 proteins slightlyimproved survival during early sepsis at days 3–5, with 14.7 and 15.2%increases in survival, respectively, at days 3 and 5 compared to the wild-type mice.Of note, survival in the late sepsis phase was improved by 80% in the S100A9 knockout(S100A9−/−) vs. wild-type mice (Figure 2A). Here, IGKV1D-22 is linked to Sepsis.