We previously reported that miR-21 and miR-181b induction during sepsis is dependenton both C/EBPβ expression and Stat3 phosphorylation, which synergize toactivate miR-21 and miR-181b promoters (37).To determine whether decreased miR-21 and miR-181b expression in S100A9 knockout miceduring late sepsis is due to lack of C/EBPβ expression and/or Stat3phosphorylation, we examined C/EBPβ and phosphorylated Stat3 protein levelsin the Gr1+CD11b+ cell lysates. The gene discussed is CEBPB; the disease is Sepsis.