DosR antigens Rv2029c of M. tuberculosis induced higher frequencies of CD4+ or CD8+ T cells producing interferon gamma (IFN-γ) and/or tumor necrosis alpha (TNF-α) in patients with long-term latent tuberculosis infection (ltLTBI), compared to those with pulmonary tuberculosis (PTB) (Riano et al., 2012; Araujo et al., 2015; Arroyo et al., 2016). This evidence concerns the gene IFNG and pulmonary tuberculosis.