Since glucagon is the major factor to recover blood glucose in glucose deprivation status, insufficient blood glucagon may potentially result in fatal hypoglycemia (Zoungas et al., 2010; Malmgren and Ahrén, 2015), which affects many PCOS patients (Altuntas et al., 2005; Barry et al., 2011). The gene discussed is GCG; the disease is Hypoglycemia.