Indeed, we have recently provided evidence for a critical role of mitochondrial cholesterol loading in the aggravation and acceleration of AD through the generation of a novel genetic mouse model of AD characterized by the overexpression of SREBP-2 in the background of APP/PS1 transgenic (APP/PS1/SREBP2; Barbero-Camps et al., 2013). Here, PSEN1 is linked to Alzheimer disease.