Moreover, PSEN1/2 and γ-secretase are located predominantly at the MAM (Area-Gomez et al., 2012), in concordance with observations that localize Aβ within mitochondria in AD-patients and transgenic AD-mice (Lustbader et al., 2004; Caspersen et al., 2005), and in neuroblastoma cells (Hayashi et al., 2012; Zheng et al., 2013). This evidence concerns the gene PSEN1 and Alzheimer disease.