STAR and Alzheimer disease: The mitochondrial transport of GSH from cytosol where it is synthesized de novo from its constituent aminoacids is dependent on mitochondrial membrane composition and fluidity (Ribas et al., 2014) and accumulation of cholesterol in IMM governed by StARD1 affects biophysical membrane properties, function and antioxidant defense, which overall contribute to the pathology of AD (Figure 4).