HSPA5 and Alzheimer disease: In fact, treatment with ER stress inhibitors such as TUDCA blocked Aβ-induced mGSH depletion (Barbero-Camps et al., 2014) and the immunoreactivity of the ER stress marker GRP78 correlated with Braak AD-stages in postmortem AD-brains, which also exhibit alterations in proteins levels of the ER stress components (Placido et al., 2014).