HSPA5 and Alzheimer disease: This outcome may be of relevance as GRP78 levels correlate with Braak staging of patients with AD and increased expression of GRP78 in AD models constitutes an early molecular event in the Aβ-induced ER stress leading to mGSH depletion through mitochondrial cholesterol loading, causing neurotoxicity and neuroinflammation (Barbero-Camps et al., 2014; Placido et al., 2014).