Some of the genes residing in these pathways comprised the enzymes involved in degradation of carbohydrates into short-chain fatty acids (SCFAs), such as hexokinase [EC: 2.7.1.1] (K00844),(10) phosphoenolpyruvate carboxykinase [EC: 4.1.1.32] (K01596)(11) and acetyl-CoA synthetase [EC: 6.2.1.1] (K01895).(11) Thus, these findings may imply pathophysiological alterations of SCFAs profiles in the gut of diabetic patients, as previously suggested.(1) Regarding other 10 significantly different pathways, the relation with type 2 diabetes is not simply interpreted. This evidence concerns the gene ACSS2 and type 2 diabetes mellitus.