We previously demonstrated that rice-derived peptides restored the expression of γ-GCS in mice with APAP-induced liver injury in addition to restoring glutathione levels.(4) A previous study reported that induction of HO-1 expression contributes to protection against liver damage induced by APAP.(5) Moreover, Nrf2-deficient mice have been reported to exhibit increased sensitivity to APAP.(6) Therefore, Nrf2 has recently been implicated as a new therapeutic target for the treatment of liver disease.(7). The gene discussed is NFE2L2; the disease is liver disorder.