UCP1 and obesity due to melanocortin 4 receptor deficiency: Oleuropein attenuates visceral adiposity in mice with HFD-induced obesity(24) and reverses the HFD-induced elevations of adipogenesis-related gene expression.(24) Oi-Kano et al.(25) suggested that oleuropein enhanced thermogenesis by increasing the level of the uncoupling protein 1 (UCP1) in interscapular brown adipose tissue and secretion of noradrenalin and adrenaline.