Some studies have demonstrated the anti-obesity and anti-hypolipidemic effects of oleuropein.(21,24) In Wistar rats fed a high-carbohydrate and HFD for 16 weeks, treatment with olive leaf extracts including oleuropein and hydroxytyrosol reduced abdominal fat circumference and fat pads without changing body weights in either of the two groups.(21) Oi-Kano et al.(25,44) reported oleuropein-activated thermogenesis through UCP1 expression and beta adrenalin receptors. Here, UCP1 is linked to obesity due to melanocortin 4 receptor deficiency.