PTEN and cancer: The intracellular ROS level can affect the phosphoinositide 3-kinase (PI3K) pathway, which induces to initiate cell proliferation, promote survival, and increase cellular mobility in cancer cells.(28) ROS inactivate phosphatase and tensin homologue (PTEN), known as a PI3K negative regulator.(29) Akt is activated by PI3K and phosphorylate several protein to regulate cell proliferation and survival.(30) Pelicano et al.(31) reported that mitROS inhibited PTEN and activated Akt specifically.