The intracellular ROS level can affect the phosphoinositide 3-kinase (PI3K) pathway, which induces to initiate cell proliferation, promote survival, and increase cellular mobility in cancer cells.(28) ROS inactivate phosphatase and tensin homologue (PTEN), known as a PI3K negative regulator.(29) Akt is activated by PI3K and phosphorylate several protein to regulate cell proliferation and survival.(30) Pelicano et al.(31) reported that mitROS inhibited PTEN and activated Akt specifically. Here, AKT1 is linked to cancer.