In this study, we have elucidated a relationship between non-heme iron transport and mitROS by studying the influence of non-heme iron incorporated by a normal rat gastric mucosal cell line, its cancer-like derivative, and its cancer-like derivative overexpressing manganese superoxide dismutase (MnSOD), a superoxide-scavenging enzyme that expresses in the mitochondrion specifically, facilitating the study of the effect of mitochondrion-derived ROS.(18). Here, SOD2 is linked to cancer.