Downregulation of monocyte IMPDH2 (β = −0.496, p = 0.004) and TMEM134 (β = −0.314, p = 0.043) was associated with obesity in adults (BMI >30 kg/m2), paralleling our findings in children. The gene discussed is IMPDH2; the disease is obesity due to melanocortin 4 receptor deficiency.