CD4 and breast carcinoma: However, IL-6 induced Tyr705 phosphorylation was unaffected in Trpm7R/R CD4+ T cells, suggesting that this signalling event is not involved in the defect in TH17 polarization of Trpm7R/R cells; this result also suggests that in breast cancer cells Tyr705 phosphorylation might be conditioned indirectly by the TRPM7 channel rather than kinase moiety.