ORAI2 and liver dysplastic nodule: In the Pima Indian study cohort, patients with DN at early stage (normal GFR or hyperfiltration stage), a small increasing trend but not statistically significant was observed for ORAI2 expression in the tubulointerstitium (Supplementary Fig. 2f), suggesting that downregulation of ORAIs is associated with fast kidney function decline during the late stage of DN, but not the early stage of DN.