ORAI2 and liver dysplastic nodule: Correspondingly, human RNAseq data from DN patients with estimated glomerular filtration rate (eGFR) ranging between 12 and 60 showed that expression of ORAI2 in the tubulointerstitium was lower in patients with DN than that in controls, and positively correlated to eGFR (Supplementary Fig. 2b, c), suggesting the expression of ORAI2 in tubules is related to the severity of DN.