In an attempt to delineate the functional relationship between IL-13Rα2 and EGFRvIII in human gliomas, isogenic human glioma cell lines that expressed either IL-13Rα2, EGFRvIII, both or null were generated to recapitulate the heterogeneous nature of the human GBM tumors. This evidence concerns the gene IL13RA2 and central nervous system cancer.