In contrast, in the presence of the mutant EGFR (EGFRvIII), IL-13Rα2 interacts with EGFRvIII to promotes GBM growth through upregulation of EGFRvIII tyrosine kinase activities and subsequently the RAS/RAF/MEK/ERK and STAT3 pathways. Here, EGFR is linked to glioblastoma.