Co-immunoprecipitation confirmed that IL-13Rα2 could interact with wtEGFR in Gli36.wtEGFR and tet-induced wtEGFR expressing U251-E6 cells (Fig. 6e), and in primary wtEGFR-positive GBM patient tumor (Fig. 6f). The gene discussed is IL13RA2; the disease is glioblastoma.