Using the same Sox2 reporter described in the current study, others and we have published the novel intra-tumoral RU/RR dichotomy detectable in oestrogen receptor-positive breast cancer, triple-negative breast cancer (TNBC), oesophageal squamous cell carcinoma and ALK-positive anaplastic large cell lymphoma25–30. This evidence concerns the gene SOX2 and triple-negative breast carcinoma.