ALK and neuroblastoma: We have recently published evidence that the physical interaction between ALK and crizotinib is an important determinant of crizotinib sensitivity in NB cells, and this interaction may be affected by the mutational status of ALK. Furthermore, β-catenin, a binding partner of ALK in NB cells, can provide significant hindrance to the crizotinib—ALK binding, especially when it is highly expressed22.