Furthermore, analysis of the number of HeLa cells expressing SYG/SYGQ-NES proteins with arsenite-induced SGs showed that SYGQ-NES expression increased SG formation in a manner similar to that observed with the ALS mutants TDP-43 (Q343R) and FUS (P525L) (Fig. 6). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.