TARDBP and amyotrophic lateral sclerosis: Although the detail pathological mechanism of the SYG/SYGQ-NES protein remains unknown and requires further study, recent evidence suggests that ALS-linked RNA-binding proteins, such as TDP-43 and FUS, are mislocated to the cytoplasm and might affect target RNAs and other RNA-binding proteins, resulting in impairment of RNA metabolism and RNA quality control mechanisms, such as those associated with SGs, during neurodegeneration1,41.