These characteristics were distinct from those observed in a protein harboring a de novo design of sPFDs17 (Figs 2,5, and 8) and other ALS-linked aggregated proteins, such as SOD-1 (Fig. 3b), indicating that the artificial SYG/SYGQ-NES proteins lacking specific physiological functions associated with target RNAs effectively mimicked specific pathological features associated with ALS/FTD-linked RNA-binding proteins. Here, SOD1 is linked to frontotemporal dementia.