Using one of our previous Trp53−/− clones, we have generated further double mutants, with deletions in Brca1, Pten and Nf1 in addition to loss Trp53, as well as triple mutants lacking Trp53, Brca2 and Pten. We have also generated a Trp53 mutant derivative of a transplantable murine fallopian tube carcinoma cell line. Here, PTEN is linked to fallopian tube carcinoma.