Within the consistent A/B compartment-switching regions, we found a cytokine receptor gene cluster at 2q11.2-q12.142 which had A-type compartment in normal B cell but B-type compartment in both MM cells, and were associated with downregulated gene expression involving several interleukins IL1R1, IL1R2, IL18R1 and the cytokine MAP4K4. The gene expression changes of this locus are associated with altered TAD structures and epigenetic markers but not copy number variations (Fig. 5b, c). This evidence concerns the gene IL1R1 and Miyoshi myopathy.