In our group, we could demonstrate that coupling of the membrane HSP70–specific antibody (cmHsp70.1) on AuNPs (AuNPs-HSP70) could significantly enhance targeting and specific uptake of nanoparticles into membrane HSP70–positive mouse colon carcinoma (CT26) cells, in vitro [88]. The gene discussed is HSPA1A; the disease is colon carcinoma.