Therefore, the reduction or inhibition of intracellular HSP70 levels by different methods such as shRNA, CRISPR/Cas9 knock-out technology, aptamers or HSP70 inhibitors [5] provides a promising strategy to sensitize tumour cells towards therapy by antagonizing apoptosis and inducing Bcl-2/caspase-independent cell death [6–8]. The gene discussed is HSPA1A; the disease is neoplasm.