Our work demonstrates a novel role of nuclear PIPKIα in cellular invasiveness in breast cancer cells by coupling with Star-PAP-mediated 3′-end processing to control the expression of important anti-invasive regulators, such as CDH1, KISS1R, NME1, CDH13, WIF1, and FEZ1 (35, 36). This evidence concerns the gene FEZ1 and breast cancer.