When mice were subjected to physical exercise, however, the severe reduction of deeply invaginated caveolar structures upon syndapin III KO was associated with observations of hypertrophy, centronuclear myopathy and necrosis, that is were reminiscent of the clinical symptoms of human muscle diseases linked to CAV3 mutation (Gazzerro et al., 2010). This evidence concerns the gene PACSIN3 and autosomal dominant centronuclear myopathy.