CAV3 and caveolinopathy: Also the fact that even LGMD-1C patients with the severest cases of CAV3 missense mutations known (63TFT65del and P104L) showing full clinical symptoms do not exhibit a complete impairment of caveolae formation (Minetti et al., 1998; Minetti et al., 2002) clearly argues in favor of the view that a complete loss of caveolae is not a prerequisite for the development of caveolinopathy symptoms.