In normal pancreatic tissue, HAI-1 immunoreactivity was weak in the pancreatic duct epithelium and cells at intercalated portions of the acini (Fig. 1a; Additional file 1: Figure S1), and the immunoreactivity was mildly increased in the ductular epithelial cells in ADM near the tumor tissue (Fig. 1b). This evidence concerns the gene SPINT1 and neoplasm.