Consistently, miR-141-3p levels in PCa tissues were negatively associated with mRNA levels of the NF-κB signaling downstream genes MMP13, TWIST1 and IL11 (Additional file 10: Figure S6A-C).Taken together, expression level of miR-141-3p negatively correlates with TRAF5, TRAF6 and NF-κB activation in clinical PCa tissues. Here, TRAF5 is linked to posterior cortical atrophy.