TRAF6 and posterior cortical atrophy: Moreover, luciferase assay revealed that upregulating miR-141-3p repressed, while silencing miR-141-3p elevated the reporter activity driven by the 3’UTRs of TRAF5 and TRAF6, but not by the mutant 3’UTR of TRAF5 and TRAF6 within the miR-141-3p–binding seed regions in PCa cells (Fig. 5c-f).