On the contrary, the overexpression of the miRNAs miR-509 and miR29 has shown to increase apoptosis, inhibit cell proliferation and invasion via suppression of TNF-α or inhibition of TNFR1 expression in triple-negative and ER positive breast cancer cells, suggesting a pro-tumorigenic effect of TNF-α or its receptor in this kind of tumors [26, 27]. This evidence concerns the gene TNFRSF1A and breast cancer.