STAT3 and neoplasm: Moreover, the processing of NF-κB2 p100 to NF-κB2 p52 and the expression of c-Myc, STAT3 and p-STAT3 decreased in the RANK-N group compared with the control group (Fig. 6d), suggesting that RANK-N might inhibit tumor progression by suppressing alternative NF-κB and STAT3 signaling.