We also found that the presence of metabolic syndrome, sleep duration ≥8 h, excessive daytime sleepiness, lower insomnia complaints, and markers of chronic inflammation (CRP and ferritin) were also risk factors for this syndrome in the subpopulation of individuals with major depression, unlike self-reported severity of depression, antidepressant therapy, smoking, alcohol consumption, or benzodiazepines and Z-drugs use. The gene discussed is CRP; the disease is insomnia.