ERBB2 and neoplasm: Stinchcombe et al. [28] reported primary results from an ongoing phase 2 study (NCT02289833) of 49 patients with previously treated HER2-overexpressing advanced NSCLC who received single-agent T-DM1, showing objective tumor responses only in 4 patients with elevated (3 +) HER2 immunohistochemical expression.