Additionally, we detected the EZH2 gain frequency in melanoma subtypes and found that the frequencies of EZH2 gain in acral melanoma, mucosal melanoma, melanoma on skin with chronic sun-induced damage (CSD) and melanoma on skin without chronic sun-induced damage (non-CSD) were 21.9, 38.9, 25.0 and 33.3%, respectively (Table 1). Here, EZH2 is linked to acral lentiginous melanoma.