Glucocorticoid Receptor signaling and NRF2-Mediated Oxidative Stress Response, Extrinsic Prothrombin Activation Pathway and Airway Pathology in Chronic Obstructive Pulmonary Disease present at both timing in NDL treated MCF-7 cells confirmed a ubiquitous though less pronounced role of oxidative stress. The gene discussed is F2; the disease is chronic obstructive pulmonary disease.