Hyperglycemia may suppress myocardial caveolin-3 in a PKCβ2 dependent manner [250] and H9c2 cardiomyoblast caveolin-3 in an oxidant-dependent manner [275], while hyperinsulinemia also depresses caveolar caveolin-3 in H9c2 cells [254]. Here, CAV3 is linked to Hyperglycemia.