The few studies analyzing myocardial caveolins in T1DM have employed relatively acute models (0–6 weeks), and report a hyperglycemic depression of caveolin-3 [135, 250–253] that may contribute to diastolic dysfunction [250], impaired GLUT4 translocation [252] and I–R intolerance [251]. The gene discussed is CAV3; the disease is type 1 diabetes mellitus.