There is evidence of increased transcription of Ca2+ channels (Cacna1c, Cacna1g, Cacnb1) and Gja4 (CX-37), and differential changes in K+ channels (Kcnj11 up, Kcnb1 down) in GK T2DM rat hearts [450]. This evidence concerns the gene CACNA1G and type 2 diabetes mellitus.