HSPG2 and type 1 diabetes mellitus: Reduced PLC generation of 1,2-diacylglycerol (DAG) may impact other cellular processes [353, 354], although myocardial DAG levels are increased with more acute STZ-dependent T1DM and in autoimmune DM (biobreeding) rats [355, 356], which could destabilize the membrane [357, 358].