In our cohort of hospitalizations for individuals with SCD from both California and Georgia, using Hb SS ICD-9-CM codes only (282.61, 282.62) versus any SCD code to identify a pediatric patient with SCA improved the positive predictive value (PPV) from 84% (9,850/11,740) to 93% (7,750/8,306); however, in the adult population the PPV only slightly improved from 79% (12,229/15,435) to 81% (10,352/12,752) (Table 2). This evidence concerns the gene GSTM1 and Schnyder corneal dystrophy.